Progress in Pediatric Cardiology
Volume 26, Issue 1 , Pages 31-37, January 2009

Current practice in immunosuppression in pediatric cardiac transplantation

  • Rebecca K. Ameduri

      Affiliations

    • Division of Pediatric Cardiology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    • ,
  • Charles E. Canter

      Affiliations

    • Division of Pediatric Cardiology, Department of Pediatrics, Washington University, 1 Children's Place, St. Louis, MO 63110, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 314 454 6095; fax: +1 314 454 2561.

Abstract 

The purpose of this review is to provide an overview of the immunotherapies that are used in pediatric heart transplantation. It includes a discussion of induction therapy, maintenance immunosuppression strategies, diagnosis and management of rejection, and new therapies that are undergoing study. This review includes information on mechanism of action of the therapies, pediatric dosing, target levels, and selected side effects. Much of the practice of pediatric heart transplant is based on clinical experience, but when available appropriate evidence is referenced within this manuscript.

Keywords: Immunosuppression, Pediatric, Cardiac, Transplant

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PII: S1058-9813(08)00066-0

doi:10.1016/j.ppedcard.2008.10.004

Progress in Pediatric Cardiology
Volume 26, Issue 1 , Pages 31-37, January 2009

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