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Progress in Pediatric Cardiology
Volume 25, Issue 1
, Pages 51-56
, April 2008
Signalosomes as therapeutic targets
References
- . Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol. 2006;7:589–600
- Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses. J Cell Physiol. 2007;212:311–322
- . Compartmentation of g protein-coupled signaling pathways in cardiac myocytes. Annu Rev Pharmacol Toxicol. 2001;41:751–773
- . The where's and when's of kinase anchoring. Trends Biochem Sci. 2006;31:316–323
- The mAKAP signalosome and cardiac myocyte hypertrophy. IUBMB Life. 2007;59:163–169
- . AKAP-Lbc: a molecular scaffold for the integration of cyclic AMP and Rho transduction pathways. Eur J Cell Biol. 2006;85:603–610
- The pediatric cardiology pharmacopoeia: 2004 update. Pediatr Cardiol. 2004;25:623–646
- . Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes. J Biol Chem. 1983;258:10233–10239
- . Akap mediated signal transduction. Annu Rev Pharmacol Toxicol. 2002;42:235–257
- A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events. EMBO J. 1998;17:2261–2272
- Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation. Proc Natl Acad Sci USA. 2006;103:16574–16579
- Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum. J Biol Chem. 1995;270:9327–9333
- A-kinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart. J Cell Biol. 1998;142:511–522
- PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 2000;101:365–376
- mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. J Cell Sci. 1999;112:2725–2736
- . mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci. 2001;114:3167–3176
- Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope. Exp Cell Res. 2005;303:388–399
- Nesprin-1 and -2 are involved in the pathogenesis of Emery–Dreifuss muscular dystrophy and are critical for nuclear envelope integrity. Hum Mol Genet. 2007;
- mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. EMBO J. 2001;20:1921–1930
- PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. J Cell Biol. 2006;175:441–451
- PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex. Biochem J. 2004;381:587–592
- The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature. 2005;437:574–578
- Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop. Circ Res. 2007;100:510–519
- Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. EMBO J. 2001;20:2757–2767
- ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions. J Biol Chem. 2000;275:16609–16617
- . Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy. Circ Res. 2002;91:1103–1113
- . Cardiac ryanodine receptor phosphorylation: target sites and functional consequences. Biochem J. 2006;396:e1–e3
- Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A. 2006;103:511–518
- . Sarcoplasmic reticulum and nuclear envelope are one highly interconnected Ca2+ store throughout cardiac myocyte. Circ Res. 2006;99:283–291
- The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. J Cell Sci. 2005;118:5637–5646
- . Calcium–calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun. 2004;322:1178–1191
- The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2007;104:10140–10145
- Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII- binding domain. J Biol Chem. 1992;267:13376–13382
- A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. EMBO J. 2001;20:1651–1662
- . AKAP-Lbc Anchors Protein Kinase A and Nucleates Galpha 12-selective Rho- mediated Stress Fiber Formation. J Biol Chem. 2001;276:44247–44257
- Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex. EMBO J. 2004;23:2811–2820
- Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol. 2004;14:1436–1450
- Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy. Circ Res. 2002;91:961–969
- AKAP-Lbc nucleates a protein kinase D activation scaffold. Mol Cell. 2004;15:889–899
- Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov. 2007;6:443–453
- . The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways. Eur J Cell Biol. 2006;85:593–602
- . Inhibitors of the calcineurin/NFAT pathway. Curr Med Chem. 2004;11:997–1007
- . Therapeutic potential of VIVIT, a selective peptide inhibitor of nuclear factor of activated T cells, in cardiovascular disorders. Cardiovasc Drug Rev. 2007;25:175–187
☆ This work is supported by a grant from the National Heart, Lung, and Blood Institute.
PII: S1058-9813(07)00167-1
doi: 10.1016/j.ppedcard.2007.11.012
© 2007 Elsevier B.V. All rights reserved.
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Progress in Pediatric Cardiology
Volume 25, Issue 1
, Pages 51-56
, April 2008
